In elaborating on conclusion 5 Voegtlin states that:
The conception that pellagra is due to a dietary deficiency is, therefore, not contradicted by the available evidence. This does not imply that the disease is necessarily due to a deficiency of diet in a specific substance such as the hypothetical pellagra vitamine of Funk (1913). It is much more likely that the pellagrous syndrome is caused by a combination of the deficiencies in some of the well recognized food factors.
V. OTHER AVITAMINOSES
The role of the vitamine in the nutrition and growth of organisms other than the man is becoming a matter of interest in various ways. The construction of culture media for various strains of bacteria and the conditions favorable or unfavorable to their growth, are features of study in which the new hypothesis has demanded attention. It has already been claimed that vitamines are essential to the growth of the meningococcus, the influenza bacillus, the typhoid bacillus, the gonococcus, the pneumococcus Type I, Streptococcus hemolyticus, the diptheria bacillus, the Bacillus pertussis and certain soil organisms. If these views are confirmed it becomes evident that the means for prevention of the development of these forms may lie in the control of the vitamine content of the materials on which these forms thrive and that in the study of these types it may be possible to speed up the incubation of strains and thus hasten diagnostic measures by introducing the necessary vitamines into the culture media. These observations merely suggest the possible widening of the scope of the vitamine study in the service of man and give added reason for our keeping pace with the strides made in this particular field.
BIBLIOGRAPHY
ABDERHALDEN, E., AND LAMPE, A. E.: Z. ges. exp. Med., (1913), i, 296.
ABDERHALDEN, E., AND SCHATJMANN: Beitrag zur Kenntnis von organischer Nahrungsstoffen mit spezifischer Wirkung I. Pfluger"s Archiv. f. d. ges.
Physiol., (1918), clxxii, 1.
ABDERHALDEN, E.: Weitere Beitrage zur Kenntnis von organischen Nahrungsstoffen mit spezifischer Wirkung II. Pfulger"s Archiv. f. d. ges.
Physiol., (1920), clxxviii, 133.
ABDERHALDEN, E.: Weitere Beitrage zur Kenntnis von organischen Nahrungsstoffen mit spezifischer Wirkung III. Pfluger"s Archiv. f. d. ges.
Physiol., (1920), clxxviii, 260.
ABELS, H.: Wiener klinische Wochenschr., (1920), x.x.xiii, 899.
ABEL, J. J., AND KUBOTA, S.: On the presence of histamine in the hypophysis cerebri and other tissues of the body and its occurrence among the hydrolytic decomposition products of proteins. J. Pharmacol. and Exp.
Therap., (1919), xiii, 243.
AGULHON AND LEGROUX: Contribution a l"etude des vitamines utilisable a la culture des micro-organismes; application au bacille de l"influenza B. de Pfeiffer. Compt. rend. Acad. de Sc. Paris, (1918), clxvii, 597.
ALWENS: Osteoporosis and osteomalacia. Munch. med. Woch., (1919), lxvi, 1071.
ANDREWS: Infantile beri-beri. Phil. J. Sci., (1911), vi, B, 67.
ANGREP, G. V., AND DRUMMOND, J. C.: Note on the supposed ident.i.ty of water soluble vitamin B and secretin. J. Physiol., 1921, liv, 349.
ARON, H.: Phosphorus starvation with special reference to beri-beri. Ph.
Journ. Sci., (1910), v, B, 81.
ARON, H., AND HOCSON: Ibid., Phil. J. Sci., 1910, v, B, 98.
ARON, H.: Ueber der "Nahrwert" und die Bedeutung der Nahrungsfette.
Biochem. Ztschr., (1920), ciii, 172.
BACHMAN, FREDA: Vitamine requirements of certain yeasts. J. Biol. Chem., 1919, x.x.xix, 235.
BARLOW, T.: Meat juice for infants as antis...o...b..tic. Lancet, London, 1894, ii, 1075.
BARNES, R. E., AND HUME, E. M.: Comparison between the antis...o...b..tic properties of fresh, heated, and dried cow"s milk. Lancet, London, 1919, ii, 323.
BARNES, R. E., AND HUME, E. M.: Relative antis...o...b..tic value of fresh, dried and heated cow"s milk. Biochemical J., 1919, xiii, 306.
Ba.s.sETT-SMITH, P. W.: Preservation of lemon juice. Lancet, London, 1920, ii, 997.
Ba.s.sETT-SMITH, P. W.: Scurvy. Lancet, London, 1920, i, 1102.
BOTTOMLEY, W. B.: Some accessory factors in plant growth and nutrition.
Proc. Roy. Soc. London, 1914, Series ii, lx.x.xviii, 237, and lx.x.xix, 102 and 481.
BLUNT, K., AND w.a.n.g, CHI CHE: The present status of vitamines. J. Home Econ., 1921, xxii, 97.
BRADDON, W. L.: Causes and prevention of beri-beri, London, 1907.
BRADDON, W. L., AND COOPER, E. L.: The influence of the total fuel value of a dietary upon the quant.i.ty of vitamine required to prevent beri-beri.
British Med. J., London, 1914, 1348.
BREUER, M.: Oedemes de guerre. Bull. l"acad. roy. med. belgique, 1920, x.x.x, 31 and 99.
BRITISH MEDICAL RESEARCH COMMITTEE: Report on the present state of knowledge concerning accessory food factors. H. M. Stationery Office, Imperial House Kingsway, London, W. C. 2.
BRUNTZ, L., AND SPILLMAN, L.: Compt. rend. Soc., biol., 1919, lx.x.xii, 8.
BULLEY, E. C.: Note on Xeropthalmia in rats. Biochem. J., 1919, xiii, 103.
BYFIELD, A. H., DANIELS, A. L., AND LOUGHLIN, R.: The antineuritic and growth stimulating properties of orange juice. Am. J. Dis. of Chil., 1920, xix, 349.
CAMPBELL, M. E. D., AND CHICK, H.: The antis...o...b..tic and growth-promoting value of canned vegetables. Lancet, London, 1919, ii, 320.
CAJORI, F. A.: The nutritive value of some nuts. Proc. Soc. Exp. Biol. and Med., 1920, xvii, 78.
CAJORI, F. A.: Some nutritive properties of nuts, their proteins and content of water-soluble vitamine. J. Biol. Chem., 1920, xliii, 583.
CHAMBERLAIN: The eradication of beri-beri from the Philippine Scouts by means of a simple change in the dietary. Ph. J. of Sci., 1911, vi, B, 133.
CHAMBERLAIN, BLOOMBERGH AND KILBOURNE: A study of the influence of rice diet and of inanition on the production of multiple neuritis in fowls. Ph.
J. of Sci., 1911, vi, B, 172.
CHAMBERLAIN AND VEDDER: A contribution to the etiology of beri-beri. Ph.
J. of Sci., 1911, vi, B, 251.
CHAMBERLAIN AND VEDDER: A second contribution to the etiology of beri- beri. Ph. J. of Sci., 1911, vi, B. 395.
CHAMBERLAIN, VEDDER AND WILLIAMS: A third contribution to the etiology of beri-beri. Ph. J. of Sci., 1912, vii, B, 39.
CHICK, H., AND MARTIN, C. J.: On the heat coagulation of proteins. J.
Physiol., 1910, xl, 404.
CHICK, H.: J. Hyg., 1910, x, 237.